SUMMARY: Starting antiretroviral therapy (ART) 2 weeks rather than 2 months after beginning tuberculosis (TB) treatment led to longer survival for HIV positive people with severe immune deficiency in the CAMELIA study, researchers reported at the XVIII International AIDS Conference (AIDS 2010) last week in Vienna. Cambodian patients receiving early ART were more likely to develop immune reconstitution inflammatory syndrome (IRIS), but this was generally manageable and starting sooner reduced mortality by more than 30%.

Below is the text of a press release from the National Institute of Allergy and Infectious Diseases (NIAID), which partially funded the research, describing the study findings and their implications.

NIH-Funded Study Finds Early HAART during TB Treatment
Boosts Survival Rate in People Co-Infected with HIV and TB

A clinical trial in Cambodia has found it possible to prolong the survival of untreated HIV-infected adults with very weak immune systems and newly diagnosed tuberculosis (TB) by starting anti-HIV therapy two weeks after beginning TB treatment, rather than waiting eight weeks, as has been standard. This finding by scientists co-funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and the French National Agency for Research on AIDS and Viral Hepatitis, brings physicians closer to optimizing the treatment of severely immunosuppressed individuals with HIV-TB co-infection. The findings were presented today at the XVIII International AIDS Conference in Vienna by principal investigators Francois-Xavier Blanc, MD, Anne E. Goldfeld, MD, and Sok Thim, MD.

"These results are just one example of how our best science can advance the treatment of an important disease, TB, that exacts a huge toll among HIV-infected individuals," says NIAID Director Anthony S. Fauci, MD. "With an estimated 1.4 million HIV-infected individuals developing TB in 2008 alone, we must continue to pursue 21st-century solutions to the scourge of HIV-TB co-infection, as well as other diseases that afflict HIV-infected people."

Individuals with HIV-TB co-infection in resource-limited countries frequently come to the attention of healthcare professionals for the first time when HIV already has severely damaged their immune systems. Such people often die during the first few months after beginning TB treatment. Clinicians agree that starting anti-HIV therapy during that short window can stave off death for some patients, but data on the best time to start have proven inconclusive and opinions have varied. The dilemma is that starting anti-HIV therapy before the TB infection is under control can cause the patient to become very sick and even die from a condition known as Immune Reconstitution Inflammatory Syndrome, but starting anti-HIV therapy too late may allow the patient to die from HIV infection. TB accounted for nearly a quarter of HIV-related deaths worldwide in 2008.

The clinical trial, called the Cambodian Early versus Late Introduction of Antiretroviral Drugs (CAMELIA), or ANRS 1295, launched in January 2006 at five sites in Cambodia, a country with a high prevalence of TB and HIV. The study staff enrolled 661 volunteers ages 18 and older with newly diagnosed HIV-TB co-infection and very weak immune systems (measured as fewer than 200 CD4+ T cells per cubic millimeter of blood). The participants all began receiving treatment for TB and were assigned at random to begin antiretroviral therapy for HIV either two weeks later or eight weeks later. The volunteers received powerful antiretroviral drug cocktails known as highly active antiretroviral therapy, or HAART. Study staff followed the participants for 50 weeks after the last volunteer had enrolled in the trial, performing clinical exams and biological tests at frequent intervals to monitor participants' health and safety.

By the end of the follow-up period, 59 out of 332 participants who had started HAART two weeks after beginning TB treatment had died, while 90 out of 329 participants who started HAART eight weeks after beginning TB treatment had died. This 33 percent difference was statistically significant, leading the principal investigators to conclude that starting HAART two weeks after beginning TB treatment, rather than waiting eight weeks, boosts the chance of survival for people with HIV-TB co-infection and severely damaged immune systems.

CAMELIA was conducted within the research agenda of the Cambodian National Center for HIV/AIDS, Dermatology and STD under the leadership of Dr. Blanc of Bicetre University Hospital, France; Dr. Goldfeld of Harvard Medical School, Boston; and Dr. Sok of the Cambodian Health Committee, Phnom Penh. NIAID provided funding for the study to the Cambodian Health Committee via a grant from the Comprehensive International Program for Research on AIDS.

For more information about CAMELIA, please see Questions and Answers: The CAMELIA Clinical Trial.

Investigator affiliations: Pneumology Unit, Internal Medicine Department, Bicêtre Hospital, Assistance Publique - Hôpitaux de Paris, Le Kremlin-Bicêtre, Paris, France; Cambodian Health Committee, Phnom Penh, Cambodia; European George Pompidou Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France; Institut Pasteur in Cambodia, Phnom Penh, Cambodia; Agence Nationale de Recherche sur le SIDA et les Hépatites Virales (ANRS), Paris, France; Institut Pasteur, Paris, France; Khmer Soviet Friendship Hospital, Infectious Diseases Department, Phnom Penh, Cambodia; Donkeo Provincial Hospital, Takeo, Cambodia; Médecins Sans Frontières, Cambodia, Phnom Penh, Cambodia; Svay Rieng Provincial Hospital, Svay Rieng, Cambodia; Calmette Hospital, Phnom Penh, Cambodia; Siem Reap Referral Hospital, Siem Reap, Cambodia; Khmer Soviet Friendship Hospital, Pneumology Department, Phnom Penh, Cambodia; Division of AIDS, NIAID, National Institutes of Health, Bethesda, MD; Harvard Medical School, Boston, MA.

7/30/10

Reference
FX Blanc, T Sok, D Laureillard, and others. Significant enhancement in survival with early (2 weeks) vs. late (8 weeks) initiation of highly active antiretroviral treatment (HAART) in severely immunosuppressed HIV-infected adults with newly diagnosed tuberculosis. XVIII International AIDS Conference. Vienna, July 18-23, 2010. Abstract THLBB106.

Other Source
NIAID. NIH-Funded Study Finds Early HAART during TB Treatment Boosts Survival Rate in People Co-Infected with HIV and TB. NIH News. July 22, 2010.